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Transient Knock-Down of Prefrontal DISC1 in Immune-Challenged Mice Causes Abnormal Long-Range Coupling and Cognitive Dysfunction throughout Development
Compromised brain development has been hypothesized to account for mental illness. This concept was underpinned by the function of the …
Xiaxia Xu
,
Mattia Chini
,
Sebastian H. Bitzenhofer
,
Ileana L. Hanganu-Opatz
Last updated on Aug 14, 2025
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DOI
Developmental dysfunction of prefrontal–hippocampal networks in mouse models of mental illness
Despite inherent difficulties to translate human cognitive phenotype into animals, a large number of animal models for psychiatric …
Victoria C. Oberlander
,
Xiaxia Xu
,
Mattia Chini
,
Ileana L. Hanganu-Opatz
Last updated on Aug 14, 2025
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DOI
Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse
The long-range coupling within prefrontal-hippocampal networks that account for cognitive performance emerges early in life. The …
Joachim Ahlbeck
,
Lingzhen Song
,
Mattia Chini
,
Sebastian H Bitzenhofer
,
Ileana L Hanganu-Opatz
Last updated on Aug 14, 2025
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DOI
Sleep Loss Promotes Astrocytic Phagocytosis and Microglial Activation in Mouse Cerebral Cortex
We previously found that Mertk and its ligand Gas6, astrocytic genes involved in phagocytosis, are upregulated after acute sleep …
Michele Bellesi
,
Luisa De Vivo
,
Mattia Chini
,
Francesca Gilli
,
Giulio Tononi
,
Chiara Cirelli
Last updated on Aug 14, 2025
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DOI
Contribution of sleep to the repair of neuronal DNA double-strand breaks: evidence from flies and mice
Exploration of a novel environment leads to neuronal DNA double-strand breaks (DSBs). These DSBs are generated by type 2 topoisomerase …
Michele Bellesi
,
Daniel Bushey
,
Mattia Chini
,
Giulio Tononi
,
Chiara Cirelli
Last updated on Aug 14, 2025
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DOI
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