Preconfigured architecture of the developing mouse brain
In the adult brain, structural and functional parameters, such as synaptic sizes and neuronal firing rates, follow right-skewed and …
Mattia Chini , Marilena Hnida , Johanna K. Kostka , Yu-Nan Chen , Ileana L. Hanganu-Opatz
Last updated on Aug 14, 2025
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Preconfigured architecture of the developing mouse brain
An increase of inhibition drives the developmental decorrelation of neural activity
Throughout development, the brain transits from early highly synchronous activity patterns to a mature state with sparse and …
Mattia Chini , Thomas Pfeffer , Ileana Hanganu-Opatz
Last updated on Aug 14, 2025
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An increase of inhibition drives the developmental decorrelation of neural activity
A transient developmental increase in prefrontal activity alters network maturation and causes cognitive dysfunction in adult mice
Disturbed neuronal activity in neuropsychiatric pathologies emerges during development and might cause multifold neuronal dysfunction …
Sebastian H. Bitzenhofer , Jastyn A. Pöpplau , Mattia Chini , Annette Marquardt , Ileana L. Hanganu-Opatz
Last updated on Aug 14, 2025
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A transient developmental increase in prefrontal activity alters network maturation and causes cognitive dysfunction in adult mice
Prefrontal Cortex Development in Health and Disease: Lessons from Rodents and Humans
The role of the prefrontal cortex (PFC) takes center stage among unanswered questions in modern neuroscience. The PFC has a Janus-faced …
Mattia Chini , Ileana L. Hanganu-Opatz
Last updated on Aug 14, 2025
PDF DOI
Prefrontal Cortex Development in Health and Disease: Lessons from Rodents and Humans
Resolving and Rescuing Developmental Miswiring in a Mouse Model of Cognitive Impairment
Cognitive deficits, core features of mental illness, largely result from dysfunction of prefrontal networks. This dysfunction emerges …
Mattia Chini , Jastyn A. Pöpplau , Christoph Lindemann , Laura Carol-Perdiguer , Marilena Hnida , Victoria Oberländer , Xiaxia Xu , Joachim Ahlbeck , Sebastian H. Bitzenhofer , Christoph Mulert , Ileana L. Hanganu-Opatz
Last updated on Aug 14, 2025
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Resolving and Rescuing Developmental Miswiring in a Mouse Model of Cognitive Impairment
Neural Correlates of Anesthesia in Newborn Mice and Humans
Monitoring the hypnotic component of anesthesia during surgeries is critical to prevent intraoperative awareness and reduce adverse …
Mattia Chini , Sabine Gretenkord , Johanna K. Kostka , Jastyn A. Pöpplau , Laura Cornelissen , Charles B. Berde , Ileana L. Hanganu-Opatz , Sebastian H. Bitzenhofer
Last updated on Aug 14, 2025
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Neural Correlates of Anesthesia in Newborn Mice and Humans
Transient Knock-Down of Prefrontal DISC1 in Immune-Challenged Mice Causes Abnormal Long-Range Coupling and Cognitive Dysfunction throughout Development
Compromised brain development has been hypothesized to account for mental illness. This concept was underpinned by the function of the …
Xiaxia Xu , Mattia Chini , Sebastian H. Bitzenhofer , Ileana L. Hanganu-Opatz
Last updated on Aug 14, 2025
PDF DOI
Transient Knock-Down of Prefrontal DISC1 in Immune-Challenged Mice Causes Abnormal Long-Range Coupling and Cognitive Dysfunction throughout Development
Developmental dysfunction of prefrontal–hippocampal networks in mouse models of mental illness
Despite inherent difficulties to translate human cognitive phenotype into animals, a large number of animal models for psychiatric …
Victoria C. Oberlander , Xiaxia Xu , Mattia Chini , Ileana L. Hanganu-Opatz
Last updated on Aug 14, 2025
PDF DOI
Developmental dysfunction of prefrontal–hippocampal networks in mouse models of mental illness
Research
What we study in the Chini Lab, GIGA–ULiège.